What is an Rprofile Every time R starts, it runs through a couple of R scripts. One of these scripts is the .Rprofile. This allows users to customise their particular set-up. However, some care has to be taken, as if this script is broken, this can cause R to break. If this happens, just delete the script! Full details of how the .Rprofile works can be found in my book with Robin on Efficient R programming.